A&M On Front Lines Of Q Fever Vaccine

Last year’s Ebola outbreak, which ravaged West Africa and spread all the way to U.S. soil, drove home an important lesson: governments need to be able to quickly respond with vaccines that project against deadly infectious diseases. Unfortunately, there are many diseases for which vaccines have not yet been developed. Researchers at Texas A&M Health Science Center are working to change that for one such disease, Q fever.

Also known as Query fever, Q fever is an animal-borne bacterial infection that has affected hundreds of U.S. troops stationed in Iraq and Afghanistan, many the result of unintentional exposure to herd animal carriers or bacteria swept up by helicopter rotors.

Caused by the bacterium, Coxiella burnetii, Q fever is extremely hardy, resistant to many common disinfectants and highly infectious – inhalation of a single bacterium is sufficient to infect a person. The potent bacteria is alsoconsidered a Select Agent by the Centers for Disease Control and Prevention, meaning it can be readily weaponized, transmitted by aerosol and cause significant morbidity.

Armed with $4.8 million in funding from the Pentagon’s Defense Threat Reduction Agency (DTRA), James Samuel, Ph.D., chair of the Department of Microbial Pathogenesis and Immunology at the Texas A&M College of Medicine and holder of the Woffard Cain Endowed Chair in Infectious Disease, is working to make a licensed vaccine for Q fever a reality.

“Most people have never heard of Q fever, but it is actually quite common,” Samuel said. “The diagnostic gap occurs because the disease presents with flu-like symptoms, so most people just think they just have the flu. But Q fever flu-like symptoms can range from asymptomatic to severely debilitating.”

In fact, with such a range of symptoms – fever, fatigue and muscle pains (to name a few) – Q fever is often under-diagnosed. While the disease occurs worldwide with acute and chronic manifestations, mortality from Q fever is unlikely.

Continue reading on Vital Record.